Blood expert zeros in on vaccine blood-clotting cause


Prof Andreas Greinacher 

A German blood expert has conducted research that he says sheds light on why the Johnson & Johnson and AstraZeneca vaccines have triggered rare but serious blood clot conditions in a few vaccine recipients.

Andreas Greinacher, a researcher at the University of Greifswald, believes so-called viral vector vaccines could cause an autoimmune response that leads to blood clots in a small number of people. He believes that reaction could be tied to stray proteins and a preservative used in the vaccines.

“We strongly support raising awareness of the signs and symptoms of this very rare event, and we are currently exploring a potential collaboration with Dr. Greinacher,” a Johnson & Johnson spokesman told the Wall Street Journal.

Related Links:

Is a preservative in AstraZeneca's vaccine to blame for rare blood clots? German scientist claims chemical can trigger an immune chain reaction that leads to rare side effect (DailyMail)

EMA: AstraZeneca Covid19 Vaccine causes serious rare ADEs - https://european-biotechnology.com/up-to-date/latest-news/news/ema-azd1222-causes-serious-rare-ades.html

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination



Ingredients of AstraZeneca Vaccine:

Recombinant, replication-deficient chimpanzee adenovirus vector — active ingredient

Histidine — amino acid

Histidine hydrochloride monohydrate — amino acid salt

Sodium chloride — salt

Magnesium chloride hexahydrate — salt

Disodium edetate (EDTA) — salt

Sucrose — sugar

Ethanol absolute — alcohol

Polysorbate 80 — surfactant



Ingredients of Pfizer-Biontech Vaccine

Nucleoside-modified messenger RNA — active ingredient

((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate) (ALC-0315) — lipid casing

2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide (ALC-0159) — lipid casing

Distearoylphosphatidylcholine (DSPC) — lipid casing

Cholesterol — lipid casing

Potassium chloride — salt

Monobasic potassium phosphate — salt

Sodium chloride — salt

Dibasic sodium phosphate dihydrate — salt

Sucrose — sugar

Water for injections


Ingredients of Moderna Vaccine

Messenger ribonucleic acid (mRNA), 

Lipids (SM-102, polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG],

cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC]),


tromethamine hydrochloride, 

acetic acid, 

sodium acetate trihydrate, 



Johnson & Johnson's (the Janssen) COVID-19 Vaccine includes the following ingredients

Recombinant, replication-incompetent adenovirus type 26 expressing the SARS-CoV-2 spike protein, 

citric acid


trisodium citrate dihydrate, 


2-hydroxypropyl-β-cyclodextri n (HBCD),


sodium chloride.


Sputnik V Ingredients  

The Gam-COVID-Vac is a two-vector vaccine. The active component for both vectors is a modified (recombinant) replication-defective adenovirus of a different serotype (Serotype 26 containing (1.0 ± 0.5) × 1011 particles of gene for the first vaccination and serotype 5 containing (1.0 ± 0.5) × 1011 particles of gene for the second vaccination), which has been modified to include the spike protein-expressing gene of SARS-CoV-2.

The other ingredients are the same, both quantitatively and qualitatively, in the two components.

No adjuvants and no other components or ingredients should be included in the vaccine.


Additional Notes

Salts such as sodium chloride to keep the vaccine solution stable at a particular pH.

sucrose (table sugar) in the Pfizer vaccine protect the formula at sub-zero temperatures.

the compound called polyethylene glycol (PEG) forms part of the lipid casing

The AstraZeneca option contains ethanol absolute and histidine, substances work together to "mop up" free radicals that would otherwise contribute to the adenovirus degrading over time, and the vaccine losing potency.

AstraZeneca has an additive called Polysorbate 80. Polysorbate 80 is a non-ionic surfactant, which is necessary to prevent adsorption of adenovirus vaccine to glass surfaces of the inside of the vial during storage.

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